Anticonvulsant Activity of N‐Palmitoylethanolamide, a Putative Endocannabinoid, in Mice
@article{Lambert2001AnticonvulsantAO, title={Anticonvulsant Activity of N‐Palmitoylethanolamide, a Putative Endocannabinoid, in Mice}, author={Didier M. Lambert and S{\'e}verine Vandevoorde and G{\'e}rald Diependaele and Sophie J. Govaerts and Annie R. Robert}, journal={Epilepsia}, year={2001}, volume={42} }
Summary: Purpose: The purpose of this study was to evaluate in mice the anticonvulsant potential of N‐palmitoylethanolamide, a putative endocannabinoid that accumulates in the body during inflammatory processes.
136 Citations
Selective Antiepileptic Effects of N‐Palmitoylethanolamide, a Putative Endocannabinoid
- BiologyEpilepsia
- 2004
Whether N‐palmitoylethanolamide (PEA), a putative endocannabinoid, would be effective against kindled amygdaloid seizures was determined and the effectiveness of PEA against pentylenetetrazol (PTZ)‐induced convulsions was tested.
Pharmacology of Palmitoylethanolamide and Related Compounds
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- 2005
Anandamide (AEA) is an endogenous fatty acid which activates the same cannabinoid receptors as ∆9-tetrahydrocannabinol, the psychoactive substance in marijuana. In vivo, anandamide exerts a number ...
N-palmitoylethanolamide derivatives: synthesis and studies on anticonvulsant and antidepressant activities
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A series novel of N-palmitoylethanolamide derivatives was synthesized and screened for their anticonvulsant and antidepressant activities. Anticonvulsant activities and neurotoxicities of compounds…
The Effect of Palmitoylethanolamide Analogue, N-(2-Morpholinoethyl) Palmitoylamide on Pain Behaviour in Mice
- Biology
- 2008
The results demonstrated that the PEA analogue exhibit central and peripheral antinociceptive activity in a dose-dependent manner presents a novel analgesic compound that may target the endogenous cannabinoid system for treatment of analgesic disorders.
The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.
- Biology, ChemistryJournal of medicinal chemistry
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The endocannabinoid system : drug targets, lead compounds, and potential therapeutic applications, and possible therapeutic applications.
The Potential Benefits of Palmitoylethanolamide in Palliation: A Qualitative Systematic Review
- MedicineThe American journal of hospice & palliative care
- 2019
There is lesser evidence of benefit in patients with nonpain symptoms related to depression, Parkinson disease, strokes, and autism, and further research is needed to define the palliative benefits to PEA.
Palmitoylethanolamide (PEA) as a Potential Therapeutic Agent in Alzheimer’s Disease
- BiologyFront. Pharmacol.
- 2019
The potential neuroprotective effects of PEA have been demonstrated in several experimental models of Alzheimer’s disease and a single-photon emission computed tomography case study reported that a mild cognitive impairment patient, treated for 9 months with ultramicronized-PEA/luteolin, presented an improvement of cognitive performances.
Non-endocannabinoid N-Acylethanolamines and Monoacylglycerols: Old Molecules New Targets
- Biology, Chemistry
- 2015
Modifications of the ethanolamine head in N-palmitoylethanolamine: synthesis and evaluation of new agents interfering with the metabolism of anandamide.
- Chemistry, BiologyJournal of medicinal chemistry
- 2003
It is concluded that although none of the PEA derivatives were dramatically more potent than PEA itself at reducing the metabolism of AEA, the lack of effect of the compounds at CB(1) and CB(2) receptors makes them useful templates for development of possible therapeutic FAAH inhibitors.
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