Anticonvulsant Activity of Azirino[1,2-d] [1,4]Benzodiazepines and Related 1,4-Benzodiazepines in Mice

@article{Sarro1997AnticonvulsantAO,
  title={Anticonvulsant Activity of Azirino[1,2-d] [1,4]Benzodiazepines and Related 1,4-Benzodiazepines in Mice},
  author={G. Sarro and A. Chimirri and R. Mckernan and K. Quirk and P. Giusti and A. Sarro},
  journal={Pharmacology Biochemistry and Behavior},
  year={1997},
  volume={58},
  pages={281-289}
}
The anticonvulsant properties of several 1,4-benzodiazepine and azirino[1,2-d][1,4]benzodiazepine (ABDZ) derivatives were studied after intraperitoneal (IP) administration in DBA/2 mice (a strain genetically susceptible to sound-induced seizures) and in Swiss mice. The anticonvulsant effects were evaluated on seizures evoked by means of auditory stimulation (109 dB, 12-16 kHz) in animals placed singly under a hemispheric Perspex dome or on seizures induced by administration of… Expand
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