Anticodon-like binding of the HIV-1 tRNA-like element to human lysyl-tRNA synthetase.

@article{Liu2016AnticodonlikeBO,
  title={Anticodon-like binding of the HIV-1 tRNA-like element to human lysyl-tRNA synthetase.},
  author={Sheng Liu and Roopa Comandur and Christopher P Jones and Pearl Tsang and Karin Musier-Forsyth},
  journal={RNA},
  year={2016},
  volume={22 12},
  pages={1828-1835}
}
A critical step in the HIV-1 lifecycle involves reverse transcription of the viral genomic RNA (gRNA). Human tRNALys3 serves as a primer for transcription initiation and is selectively enriched in virus particles. Human lysyl-tRNA synthetase (hLysRS) is also packaged into virions. Recently, a tRNA-like element (TLE) within the HIV-1 gRNA was shown to mimic… CONTINUE READING