Anticoagulation with nafamostat mesilate, a synthetic protease inhibitor, in hemodialysis patients with a bleeding risk.

@article{Matsuo1993AnticoagulationWN,
  title={Anticoagulation with nafamostat mesilate, a synthetic protease inhibitor, in hemodialysis patients with a bleeding risk.},
  author={Takefumi Matsuo and Kazuomi Kario and K. Nakao and Takayuki Yamada and Masanao Matsuo},
  journal={Haemostasis},
  year={1993},
  volume={23 3},
  pages={135-41}
}
Nafamostat mesilate (FUT) is a synthetic serine protease inhibitor with a short half-life that is used during hemodialysis (HD) in patients with a high risk of bleeding because it does not prolong the systemic coagulation time. To evaluate whether or not FUT is able to effectively prevent clot formation in the extracorporeal circuit without increasing systemic bleeding, HD using FUT was carried out for 33 sessions in 12 patients with a high risk of bleeding. FUT was continuously infused during… CONTINUE READING