Anticoagulation therapy for patients with non-valvular atrial fibrillation: comparison of decision analytic model recommendations and real-world warfarin prescription use.

@article{Casciano2012AnticoagulationTF,
  title={Anticoagulation therapy for patients with non-valvular atrial fibrillation: comparison of decision analytic model recommendations and real-world warfarin prescription use.},
  author={Julian P Casciano and Daniel E. Singer and Winghan Jacqueline Kwong and Eben S Fox and Bradley C. Martin},
  journal={American journal of cardiovascular drugs : drugs, devices, and other interventions},
  year={2012},
  volume={12 5},
  pages={313-23}
}
BACKGROUND Anticoagulation in patients with atrial fibrillation (AF) is challenging because stroke-risk reduction must be balanced against increased bleeding risk. OBJECTIVE We developed a decision model integrating both stroke and bleeding risk schemes to guide optimal use of anticoagulation in AF, and compared model recommendations with warfarin use in a real-world database. METHODS A Markov model based on demographics, CHADS(2) (Congestive Heart Failure, Hypertension, Age of 75 years and… CONTINUE READING