Anticoagulation and pediatric extracorporeal membrane oxygenation: impact of activated clotting time and heparin dose on survival.

@article{Baird2007AnticoagulationAP,
  title={Anticoagulation and pediatric extracorporeal membrane oxygenation: impact of activated clotting time and heparin dose on survival.},
  author={Christopher W. Baird and David Zurakowski and Barbara Robinson and Sanjiv K. Gandhi and Leighann Burdis-Koch and Joseph Tamblyn and R. Mu{\~n}oz and Karol Fortich and Frank A. Pigula},
  journal={The Annals of thoracic surgery},
  year={2007},
  volume={83 3},
  pages={912-9; discussion 919-20}
}
BACKGROUND Anticoagulation during pediatric extracorporeal membrane oxygenation (ECMO) is accomplished by titrating heparin administration to maintain an activated clotting time (ACT) of between 180 and 220 seconds. We hypothesized that an ACT of 180 to 220 seconds results in inadequate anticoagulation during pediatric ECMO and that increased heparin levels will lead to increased survival. METHODS A retrospective review was conducted of 604 consecutive pediatric ECMO patients at a single… CONTINUE READING
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