Anticoagulant therapy in Japanese patients with mechanical mitral valves.

  title={Anticoagulant therapy in Japanese patients with mechanical mitral valves.},
  author={Katsuhiko Matsuyama and Masahiko Matsumoto and Takaaki Sugita and Junichiro Nishizawa and Kazunori Yoshida and Yoshiyuki Tokuda and Takehiko Matsuo},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  volume={66 7},
There are no guidelines for the optimal therapeutic range of anticoagulant therapy in Japanese patients with mechanical heart valves. A total of 214 patients were followed retrospectively after mitral mechanical valve replacement (mean duration of follow-up, 4.8 years; total duration of follow-up, 1,027 patient-years). The target range of the international normalized ratio (INR) for oral anticoagulation was between 1.5 and 2.5. For all patients 10,416 measurements of the INR were obtained… CONTINUE READING


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