Anticoagulant peptides; synthesis, stability and antithrombin activity of hirudin C-terminal-related peptides and their disulfated analog.

@article{Okayama1996AnticoagulantPS,
  title={Anticoagulant peptides; synthesis, stability and antithrombin activity of hirudin C-terminal-related peptides and their disulfated analog.},
  author={Toru Okayama and Ryo Muramatsu and Sachiko Seki and Emiko Nukui and Masaki Hagiwara and Hideya Hayashi and Tadanori Morikawa},
  journal={Chemical & pharmaceutical bulletin},
  year={1996},
  volume={44 7},
  pages={1344-50}
}
We designed a unique anticoagulant decapeptide, which possesses two O-sulfated tyrosine residues, based on the structure of hirudin's C-terminal functional domain. We first prepared a series of octa-, nona- and decapeptides with no sulfation, Suc-Phe-Glu-Pro-Ile-Pro-Glu-Tyr-Tyr-X-OH [X = bond, Leu or Leu-Gln], by a solution phase method and measured their… CONTINUE READING