Anticoagulant activity of a synthetic heparinoid in relation to molecular weight and N-sulfate content.

Abstract

Addition of chlorosulfonyl isocyanate to C==C bonds in cis-1,4-polyisoprene and reaction of the adduct with NaOH resulted in the formation of a water-soluble polyelectrolyte with N-sulfate and carboxylate groups. The polyelectrolyte showed anticoagulant activity and it was found, just as with heparin, that the activity was related to molecular weight and N-sulfate content.

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Cite this paper

@article{Sederel1981AnticoagulantAO, title={Anticoagulant activity of a synthetic heparinoid in relation to molecular weight and N-sulfate content.}, author={L C Sederel and Lisette J. M. E. van der Does and J F van Duijl and T . Beugeling and Adriaan Bantjes}, journal={Journal of biomedical materials research}, year={1981}, volume={15 6}, pages={819-27} }