Anticoagulant activity of Hirulog, a direct thrombin inhibitor, in humans.

@article{Fox1993AnticoagulantAO,
  title={Anticoagulant activity of Hirulog, a direct thrombin inhibitor, in humans.},
  author={Irlbacher Fox and Andrew H. Dawson and Peter Loynds and Janis Eisner and K Findlen and Elena Levin and Dennis Hanson and Tim G Mant and Jonathan B Wagner and John M. Maraganore},
  journal={Thrombosis and haemostasis},
  year={1993},
  volume={69 2},
  pages={
          157-63
        }
}
Hirulog (BG8967) is a direct thrombin inhibitor built by rational design using the protein hirudin as a model (Maraganore et al. [1990]; Biochemistry 29: 7095-101). In order to evaluate the therapeutic potential for hirulog in the management of thrombotic disease, the tolerability and anticoagulant activity of the agent were examined in a study of human volunteers. In a randomized, placebo-controlled study (n = .54), the intravenous infusion of hirulog over 15 min showed a rapid, dose-dependent… CONTINUE READING
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