Anticoagulant activities of piperlonguminine in vitro and in vivo

  title={Anticoagulant activities of piperlonguminine in vitro and in vivo},
  author={Wonhwa Lee and Hayoung Yoo and Sae Kwang Ku and Jeong Ah Kim and Jong-Sup Bae},
  booktitle={BMB reports},
Piperlonguminine (PL), an important component of Piper longum fruits, is known to exhibit anti-hyperlipidemic, anti-platelet and anti-melanogenic activities. Here, the anticoagulant activities of PL were examined by monitoring activated-partial-thromboplastin-time (aPTT), prothrombin-time (PT), and the activities of thrombin and activated factor X (FXa). The effects of PL on the expressions of plasminogen activator inhibitor type 1 (PAI-1) and tissue-type plasminogen activator (t-PA) were also… CONTINUE READING
7 Citations
29 References
Similar Papers


Publications referenced by this paper.
Showing 1-10 of 29 references

Alkamides and their biological activity from Piper longum Linn

  • G. V. Rao, K. S. Rao, T. Mukhopadhyay, M.S.L. Madhavi
  • J. Pharm Res
  • 2012

Similar Papers

Loading similar papers…