Anticlastogenic effects of 13-cis-retinoic acid in vitro.

  title={Anticlastogenic effects of 13-cis-retinoic acid in vitro.},
  author={Z Trizna and Tao C. Hsu and Stimson Pryor Schantz and J Jack Lee and Waun Ki Hong},
  journal={European journal of cancer},
  volume={29A 1},
The anticlastogenic effects of 13-cis-retinoic acid were studied in four human lymphoblastoid cell lines and in primary lymphocyte cultures derived from the peripheral blood of 11 study subjects. Cells were pre-incubated with 13-cis-retinoic acid in the concentration range of 10(-8)-10(-5) mol/l for 24 h and the numbers of chromatid breaks per cell induced by bleomycin were determined. The presence of 13-cis-retinoic acid decreased the number of breaks per cell by 13.0 to 59.5% in… CONTINUE READING