Anticipation or ascertainment bias in schizophrenia? Penrose's familial mental illness sample.

@article{Bassett1997AnticipationOA,
  title={Anticipation or ascertainment bias in schizophrenia? Penrose's familial mental illness sample.},
  author={Anne S. Bassett and John D Husted},
  journal={American journal of human genetics},
  year={1997},
  volume={60 3},
  pages={
          630-7
        }
}
Several studies have observed anticipation (earlier age at onset [AAO] in successive generations) in familial schizophrenia. However, whether true anticipation or ascertainment bias is the principal originating mechanism remains unclear. In 1944 L. S. Penrose collected AAO data on a large, representative sample of familial mental illness, using a broad ascertainment strategy. These data allowed examination of anticipation and ascertainment biases in five two-generation samples of affected… CONTINUE READING

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