Anticipation of emotionally aversive visual stimuli activates right insula

  title={Anticipation of emotionally aversive visual stimuli activates right insula},
  author={Alan N. Simmons and Scott C. Matthews and Murray B. Stein and Martin P. Paulus},
Understanding the neural substrates of anticipation is required for a comprehensive model of the ways in which anxiety influences information processing. While it is apparent that the insula and medial frontal cortex are involved in processing anticipation of physical (i.e., painful) stimuli, their role in processing anticipation of aversive affective stimuli has yet to be determined. Twenty-eight healthy non-phobic volunteers observed aversive affective images (spiders and snakes) that were… 
Feeling anxious: anticipatory amygdalo-insular response predicts the feeling of anxious anticipation.
The results provide evidence for an amygdalo-insular system involved in anxious auditory anticipation, and reactivity in the right anterior insula was predictive of individuals' subjective experience of anxious anticipation for both aversive and neutral stimuli, whereas the amygdala was predicted of anticipatory anxiety for aversive stimuli.
Anticipation of Aversive Visual Stimuli Is Associated With Increased Insula Activation in Anxiety-Prone Subjects
Anticipation of high arousal aversive and positive movie clips engages common and distinct neural substrates.
Results suggest that a common circuitry is recruited in anticipation of affective clips regardless of valence, with additional areas preferentially engaged depending on whether expected stimuli are negative or positive.
Neural bases of affective anticipation : an fMRI study
Comparing findings obtained under negative and positive anticipation conditions suggests that anticipatory activation of the limbic system may facilitate preparatory processes in the prefrontal cortex in anticipation of negative images.
Anxiety positive subjects show altered processing in the anterior insula during anticipation of negative stimuli
Both groups showed greater activation in the bilateral anterior insula during cued differential anticipation, and activation on the right was significantly higher in AP compared to AN subjects, consistent with the hypothesis that anxiety is related to greater anticipatory reactivity in the brain and that there may be functional asymmetries in thebrain that interact with psychiatric traits.
Modality-specific effects of aversive expectancy in the anterior insula and medial prefrontal cortex
The data suggest that the insular cortex encodes prospective aversive events in terms of their modality-specific features, and whether they match with subsequent stimulations.
Anticipation of aversive stimuli activates extended amygdala in unipolar depression.


Does Anticipation of Pain Affect Cortical Nociceptive Systems?
FMRI results suggest that the activity of cortical nociceptive networks may be directly influenced by cognitive factors, and provide evidence for top-down mechanisms, triggered by anticipation, modulating cortical systems involved in sensory and affective components of pain even in the absence of actual noxious input.
Emotion-induced changes in human medial prefrontal cortex: II. During anticipatory anxiety.
Regional cerebral blood flow was examined in the human medial prefrontal cortex with positron emission tomography during anticipatory anxiety and changes in MPFC and in the midbrain were correlated with each other and with anxiety self rating.
Amygdala and anterior cingulate cortex activation during affective startle modulation: a PET study of fear
It is suggested that the amygdaloid area and the ACC form part of a neural system dedicated to attention and orientation to danger, and that this network modulates startle during negative affect.
Neural Correlates of Conscious Self-Regulation of Emotion
Findings reinforce the view that emotional self-regulation is normally implemented by a neural circuit comprising various prefrontal regions and subcortical limbic structures and suggest that humans have the capacity to influence the electrochemical dynamics of their brains, by voluntarily changing the nature of the mind processes unfolding in the psychological space.
Dissociating pain from its anticipation in the human brain.
Functional magnetic resonance imaging in healthy humans was applied to dissociate neural activation patterns associated with acute pain and its anticipation to find sites within the medial frontal lobe, insular cortex, and cerebellum distinct from, but close to, locations mediating pain experience itself.
A Functional Anatomy of Anticipatory Anxiety
Findings support the role of paralimbic structures as neural substrates of anticipatory anxiety and the failure to demonstrate behavioral and neurophysiological changes with the distractor task may reflect the modest increases in anxiety with the shock, the relatively simple distractionor task, and small sample size.
Central neural mechanisms that interrelate sensory and affective dimensions of pain.
  • D. Price
  • Biology, Psychology
    Molecular interventions
  • 2002
Indirect cortico-limbic pathways integrate nociception with information about the status of the body and indirect routes must culminate in the prioritization of emotions and responses to pain.
Expectation of Pain Enhances Responses to Nonpainful Somatosensory Stimulation in the Anterior Cingulate Cortex and Parietal Operculum/Posterior Insula: an Event-Related Functional Magnetic Resonance Imaging Study
It is suggested that ACC and PO/PI are involved in modulation of affective aspect of sensory perception by the uncertain expectation of painful stimulus.