Anticipation of age at onset in familial multiple sclerosis.

  title={Anticipation of age at onset in familial multiple sclerosis.},
  author={Luc{\'i}a Romero-Pinel and Sergio Mart{\'i}nez-Y{\'e}lamos and Laura Gubieras and Elisabet Matas and Laura Bau and Marcelo Kremenchutzky and Txomin Arbizu},
  journal={European journal of neurology},
  volume={17 4},
BACKGROUND AND OBJECTIVE Anticipation of age at onset in the younger generations is a widely known characteristic of many diseases with genetic inheritance. This study was performed to assess whether there is anticipation of age at onset in younger generations of familial multiple sclerosis (MS) in a Spanish population and to compare clinical characteristics of familial and sporadic MS. METHODS We studied a cohort of 1110 patients diagnosed with MS and followed-up in our MS Unit. Patients… CONTINUE READING