Anticipating an RNA World Some Past Speculations on the Origin of Life: Where Are They Today?

@article{Orgel1993AnticipatingAR,
  title={Anticipating an RNA World Some Past Speculations on the Origin of Life: Where Are They Today?},
  author={L. Orgel and F. Crick},
  journal={The FASEB Journal},
  year={1993},
  volume={7}
}
About 25 years ago, one of us (L.E.O.) was unable to fulfill a commitment to speak on the origins of life at a symposium in London, and his place was taken by the other (F.H.C.C.).i Stimulated by the symposium, each of us (unknown to the other) independently produced a manuscript covering ideas we had developed in many earlier discussions. We agreed to exchange some subject matter between the manuscripts and produced two overlapping, highly speculative papers: one concentrating on the origin of… Expand
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References

SHOWING 1-10 OF 10 REFERENCES
Genetic Takeover and the Mineral Origins of Life
A G Cairns–Smith 1982 Cambridge: Cambridge University Press ix + 477 pp price £15 Genetic Takeover is about the origins of life on earth. It presents a radical new point of view to those of us whoExpand
Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena
TLDR
It is proposed that the IVS portion of the RNA has several enzyme-like properties that enable it to break and reform phosphodiester bonds and that enzymes, small nuclear RNAs and folding of the pre-rRNA into an RNP are unnecessary for these reactions. Expand
Modern metabolism as a palimpsest of the RNA world.
An approach is developed for constructing models of ancient organisms using data from metabolic pathways, genetic organization, chemical structure, and enzymatic reaction mechanisms found inExpand
The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme
TLDR
The RNA moieties of ribonuclease P purified from both E. coli and B. subtilis can cleave tRNA precursor molecules in buffers containing either 60 mM Mg2+ or 10 mM MG2+ plus 1 mM spermidine, and in vitro, the RNA and protein subunits from one species can complement sub units from the other species in reconstitution experiments. Expand
Evolution of the genetic apparatus.
  • L. Orgel
  • Biology, Medicine
  • Journal of molecular biology
  • 1968
Abstract It is argued that the evolution of the genetic apparatus must have required the abiotic formation of macromolecules capable of residue-by-residue replication. This suggests thatExpand
Origin of the Genetic Code
TLDR
It is considered that originally only a few amino acids were coded, but that most of the possible codons were fairly soon brought into use and the code became frozen in its present form. Expand
Unusual resistance of peptidyl transferase to protein extraction procedures.
TLDR
Findings support the possibility that 23S ribosomal RNA participates in the peptidyl transferase function, as judged by specific inhibition by the peptide bond formation-specific antibiotics chloramphenicol and carbomycin. Expand
RNA-catalysed synthesis of complementary-strand RNA
The Tetrahymena ribozyme can splice together multiple oligonucleotides aligned on a template strand to yield a fully complementary product strand. This reaction demonstrates the feasibility ofExpand
The design of novel replicating polymers
  • In Encyclopaedia of Ignorance Duncan, R., and Weston-Smith,
  • 1977
Originofgenetic code. Nature(London)212, 1397 2. Crick, F. H. C. (1967) Origin of the genetic code
  • Nature
  • 1966