Anticholinesterasic drugs: tacrine but not physostigmine, accumulates in acidic compartments of the cells.

@article{Dellantone1995AnticholinesterasicDT,
  title={Anticholinesterasic drugs: tacrine but not physostigmine, accumulates in acidic compartments of the cells.},
  author={P Dell'antone and Marcantonio Bragadin and Paolo Zatta},
  journal={Biochimica et biophysica acta},
  year={1995},
  volume={1270 2-3},
  pages={137-41}
}
Tacrine (THA) and physostigmine (PHS) have been used in Alzheimer's disease therapy for their anticholinesterasic activity. Here we show that THA is taken up in rat lysosomes in an energy-dependent manner, and that it is also accumulated in acidic compartments of rat thymocytes and neuroblastoma cells. A concentration of THA less than 1 mM dissipated the pH gradient (delta pH) in all the above mentioned in vitro systems. On the contrary higher concentrations of PHS (1-2 mM) were ineffective… CONTINUE READING
6 Citations
1 References
Similar Papers

References

Publications referenced by this paper.

Methods Enzymol

  • C. De Duve, T. De Barsy, B. Poole, A. Trouet, P. Tulken, F VaanHoob
  • J. Cell. Biol
  • 1974

Similar Papers

Loading similar papers…