Anticholinesterase activity of the fusarium metabolite visoltricin and its N-methyl derivative.

  title={Anticholinesterase activity of the fusarium metabolite visoltricin and its N-methyl derivative.},
  author={M. Solfrizzo and A. Visconti},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  volume={8 3},
  • M. Solfrizzo, A. Visconti
  • Published 1994
  • Chemistry, Medicine
  • Toxicology in vitro : an international journal published in association with BIBRA
Visoltricin is a bioactive 4,5-disubstituted N-methylimidazole produced by Fusarium tricinctum, which shows toxic activity towards Artemia salina larvae and miotic activity on rabbit eye. The anticholinesterase properties and kinetic parameters of visoltricin and N-methyl visoltricin were assessed. Visoltricin anticholinesterase activity was demonstrated on human serum [median inhibitory concentration (IC(50)) = 2.6 x 10(-4)m], bovine erythrocyte acetylcholinesterase EC (IC(50) = 4 x 10… Expand
Visoltricin, a novel biologically active compound produced by Fusarium tricinctum.
Visoltricin was toxic to A. salina larvae, and inhibited the growth of six human tumour cell lines (out of 60 lines tested) at concentrations lower than 10(-5) M, and showed an interesting miotic activity similar to that of pilocarpine, a miotic agent largely used in the therapy of glaucoma. Expand
Simultaneous high-performance liquid chromatographic determination of visoltricin, acuminatopyrone and chlamydosporols in Fusarium cultures on maize.
Visoltricin was produced only by F. tricinctum, whereas ACP and chlamydosporols were produced by both Fusarium species, and the presence of ammonia in the mobile phase improved the shape of the CL and VIS peaks. Expand
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Isolation, characterization and biological activity of visoltricin, a novel metabolite of Fusarium tricinctum
It is confirmed that F. tricinctum from various substrates and geographic areas produced visoltricin when grown on corn, and it is the first imidazole derivative produced by a Fusarium species. Expand
Evaluation of kinetic constants for mixed inhibitors of cholinesterase.
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A new and rapid colorimetric determination of acetylcholinesterase activity.
A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has been described and Kinetic constants determined by this system for erythrocyte eholinesterases are presented. Expand