Anticholinergics boost the pathological process of neurodegeneration with increased inflammation in a tauopathy mouse model

@article{Yoshiyama2012AnticholinergicsBT,
  title={Anticholinergics boost the pathological process of neurodegeneration with increased inflammation in a tauopathy mouse model},
  author={Yasumasa Yoshiyama and Ayako Kojima and Kimiko Itoh and Tomoyuki Uchiyama and Kimihito Arai},
  journal={Neurobiology of Disease},
  year={2012},
  volume={45},
  pages={329-336}
}
Anticholinergics, and drugs with anticholinergic properties, are widely and frequently prescribed, especially to the elderly. It is well known that these drugs decrease cognitive function and increase the risk of dementia. Although the mechanism of anticholinergic drug-induced cognitive impairment has been assumed to be functionally reduced acetylcholine (ACh) neurotransmission, some data have indicated that anticholinergics might enhance the pathology of Alzheimer's disease. In this study, we… CONTINUE READING
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