Anticholinergic activity of the dopamine receptor agonist, TL‐68 (N,N‐dipropyl‐2‐aminotetralin)

@article{Sahin1987AnticholinergicAO,
  title={Anticholinergic activity of the dopamine receptor agonist, TL‐68 (N,N‐dipropyl‐2‐aminotetralin)},
  author={I Sahin and Mustafa Ilhan},
  journal={Journal of Pharmacy and Pharmacology},
  year={1987},
  volume={39}
}
  • I. Sahin, M. Ilhan
  • Published 1 February 1987
  • Biology, Medicine, Chemistry
  • Journal of Pharmacy and Pharmacology
The anticholinergic properties of a dopamine receptor agonist, a non‐hydroxylated derivative of N,N‐dipropylaminotetralin (TL‐68), were evaluated using the guinea‐pig isolated tracheal strip and rat phrenic nerve‐diaphragm preparations. TL‐68 competitively antagonized carbachol‐induced contractions in guinea‐pig trachea with a pA2 value of 5.88 ± 0.05. In the rat phrenic nerve‐diaphragm preparation, TL‐68 was found to be inactive in blocking nicotinic cholinergic receptors. 
1 Citations
Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) antagonize oxotremorine-induced tremors by antimuscarinic action in mice.
TLDR
Central antimuscarinic actions of dopamine receptor agonists: N,N-dipropylaminotetrain (TL-68) and RDS-127 inhibited the tremor intensity but were less potent than atropine.

References

SHOWING 1-3 OF 3 REFERENCES
Dopaminergic effects of non-hydroxylated rigid analogs of apomorphine.
The spirally cut tracheal strip preparation
TLDR
This document is intended to provide a history of the field and some of the techniques used, as well as specific cases, that were developed over a period of several years to develop a theory of pharmacology and its application in the context of modern medicine.
Cannon for the generous gift of TL-68. We also thank Dr S. 0. Kayaalp for critical reading of the manuscript