Anticholinergic activity of the dopamine receptor agonist, TL‐68 (N,N‐dipropyl‐2‐aminotetralin)

I. Şahin; M. Ilhan

DOI:10.1111/j.2042-7158.1987.tb06963.x

Corpus ID: 7454947

Anticholinergic activity of the dopamine receptor agonist, TL‐68 (N,N‐dipropyl‐2‐aminotetralin)

@article{ahin1987AnticholinergicAO,
  title={Anticholinergic activity of the dopamine receptor agonist, TL‐68 (N,N‐dipropyl‐2‐aminotetralin)},
  author={I. Şahin and M. Ilhan},
  journal={Journal of Pharmacy and Pharmacology},
  year={1987},
  volume={39}
}

I. Şahin, M. Ilhan

Published 1987

Chemistry, Medicine

Journal of Pharmacy and Pharmacology

The anticholinergic properties of a dopamine receptor agonist, a non‐hydroxylated derivative of N,N‐dipropylaminotetralin (TL‐68), were evaluated using the guinea‐pig isolated tracheal strip and rat phrenic nerve‐diaphragm preparations. TL‐68 competitively antagonized carbachol‐induced contractions in guinea‐pig trachea with a pA2 value of 5.88 ± 0.05. In the rat phrenic nerve‐diaphragm preparation, TL‐68 was found to be inactive in blocking nicotinic cholinergic receptors.

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