Anticholinergic activity of the dopamine receptor agonist, TL‐68 (N,N‐dipropyl‐2‐aminotetralin)

@article{ahin1987AnticholinergicAO,
  title={Anticholinergic activity of the dopamine receptor agonist, TL‐68 (N,N‐dipropyl‐2‐aminotetralin)},
  author={I. Şahin and M. Ilhan},
  journal={Journal of Pharmacy and Pharmacology},
  year={1987},
  volume={39}
}
  • I. Şahin, M. Ilhan
  • Published 1987
  • Chemistry, Medicine
  • Journal of Pharmacy and Pharmacology
  • The anticholinergic properties of a dopamine receptor agonist, a non‐hydroxylated derivative of N,N‐dipropylaminotetralin (TL‐68), were evaluated using the guinea‐pig isolated tracheal strip and rat phrenic nerve‐diaphragm preparations. TL‐68 competitively antagonized carbachol‐induced contractions in guinea‐pig trachea with a pA2 value of 5.88 ± 0.05. In the rat phrenic nerve‐diaphragm preparation, TL‐68 was found to be inactive in blocking nicotinic cholinergic receptors. 
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    SHOWING 1-3 OF 3 REFERENCES
    Dopaminergic effects of non-hydroxylated rigid analogs of apomorphine.
    • 24
    The spirally cut tracheal strip preparation
    • J. Constantine
    • Chemistry, Medicine
    • The Journal of pharmacy and pharmacology
    • 1965
    • 161
    Cannon for the generous gift of TL-68. We also thank Dr S. 0. Kayaalp for critical reading of the manuscript