Anticholinergic Effects on Memory: Benztropine versus Amantadine

@article{Gelenberg1989AnticholinergicEO,
  title={Anticholinergic Effects on Memory: Benztropine versus Amantadine},
  author={Alan J. Gelenberg and Theodore Van Putten and Philip W. Lavori and Joanne Doller Wojcik and William E. Falk and Stephen R. Marder and Bonnie J. Spring and Richard C. Mohs and Andrew W. Brotman},
  journal={Journal of Clinical Psychopharmacology},
  year={1989},
  volume={9},
  pages={180–185}
}
To evaluate anticholinergic effects on cognition and other functions, we studied 60 healthy volunteers in a double-blind crossover trial of two anti-parkinsonian agents, benztropine and amantadine. Benztropine 4 mg/day, but not amantadine 200 mg/ day, impaired free recall and perception of time, and subjects' perception of their own memory impairment was significantly greater with benztropine. Side effects in general were worse with benztropine, particularly such anticholinergic effects as dry… 
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