Anticholinergic Effects on Memory: Benztropine versus Amantadine

  title={Anticholinergic Effects on Memory: Benztropine versus Amantadine},
  author={Alan J. Gelenberg and Theodore Van Putten and Philip W. Lavori and Joanne Doller Wojcik and William E. Falk and Stephen R. Marder and Bonnie J. Spring and Richard C. Mohs and Andrew W. Brotman},
  journal={Journal of Clinical Psychopharmacology},
To evaluate anticholinergic effects on cognition and other functions, we studied 60 healthy volunteers in a double-blind crossover trial of two anti-parkinsonian agents, benztropine and amantadine. Benztropine 4 mg/day, but not amantadine 200 mg/ day, impaired free recall and perception of time, and subjects' perception of their own memory impairment was significantly greater with benztropine. Side effects in general were worse with benztropine, particularly such anticholinergic effects as dry… 
The effect of chlorpromazine and benzhexol on memory and psychomotor function in healthy volunteers
This study supports the contention that sedation is unlikely to be the mechanism by which anticholinergic drugs exert their amnestic effect.
Effects of Biperiden and Amantadine on Memory in Medicated Chronic Schizophrenic Patients
In usual clinical doses, biperiden interferes with memory, particularly visual, more than amantadine, in chronically medicated schizophrenic in-patients.
Increased anticholinergic levels, memory and judgement
It is argued that, in the absence of definitive findings, several clinical considerations suggest that the clinician should consider the possible impact of anticholinergics on judgement in his or her practice.
Increased mental slowing associated with the APOE epsilon4 allele after trihexyphenidyl oral anticholinergic challenge in healthy elderly.
The epsilon4 allele in healthy elderly was associated with increased subjective mental slowing after trihexyphenidyl anticholinergic challenge, and no significant effects were found with other visual analog scales reflecting subjective sedation and clear-headedness.
The effects of antipsychotic and antiparkinsonian medication on psychosocial skill learning
  • W.
  • Psychology, Medicine
  • 2021
The combined evidence suggests that low t o moderate doses of antipsychotic medication may improve psychosocial skill learning, however, high-dose antipsychotics or anticholinegic medication may actually diminish skill learning.
Antiparkinsonian Drugs in the Treatment of Neuroleptic-Induced Extrapyramidal Symptoms
Antiparkinsonian medication represents the mainstay of treatment for neuroleptic-induced extrapyramidal symptoms and their clinical use is reviewed here with reference to mode of action, indications, choice, side-effects and precautions.
The Effects of Antipsychotic and Antiparkinsonian Medication on Psychosocial Skill Learning
The combined evidence suggests that low to moderate doses of antipsychotic medication may improve psychosocial skill learning, however, high-dose antipsy-chotics or anticholinergic medication may actually diminish skill learning.
Does risperidone improve verbal working memory in treatment-resistant schizophrenia?
Results from this study suggest that pharmacotherapeutic efficacy in schizophrenia treatment could be broadened to include impact on neurocognitive abilities.
Neurocognitive Costs and Benefits of Psychotropic Medications in Older Adults
A comprehensive review of the undesirable, and at times beneficial, effects of psychotropic medications in older adults covers a wide range of medications that impair executive function, memory, and attention, as well as a much smaller group of medication that lead to improved neurocognitive function.