Anticholinergic Activity of 107 Medications Commonly Used by Older Adults

@article{Chew2008AnticholinergicAO,
  title={Anticholinergic Activity of 107 Medications Commonly Used by Older Adults},
  author={Marci L. Chew and Benoit H. Mulsant and Bruce G. Pollock and Mark E. Lehman and Andrew J. Greenspan and Ramy A. Mahmoud and Margaret A. Kirshner and Denise Sorisio and Robert R Bies and Georges M. Gharabawi},
  journal={Journal of the American Geriatrics Society},
  year={2008},
  volume={56}
}
The objective of this study was to measure the anticholinergic activity (AA) of medications commonly used by older adults. [] Key Method A radioreceptor assay was used to investigate the AA of 107 medications. Six clinically relevant concentrations were assessed for each medication. Rodent forebrain and striatum homogenate was used with tritiated quinuclidinyl benzilate. Drug-free serum was added to medication and atropine standard-curve samples.

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These guidelines have been developed using the prescribing information and reviewing the available literature on relevant neuropsychiatric disorders in populations without ID and believe that these guidelines will provide a useful resource for clinicians who treat adult individuals with IDs.

Anticholinergic Exposure in a Cohort of Adults Aged 80 years and Over

The longitudinal study among Belgian community‐dwelling oldest old demonstrated great anticholinergic exposure, which was associated with increased risk of mortality and hospitalization after 18 months, and female gender, the level of multi‐morbidity and the number of medications were associated with antICHolinergic use.

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The neural pathways of the cholinergic system are described and the main clinical uses and adverse effects of anticholinergic agents with a focus on cognitive impairment are outlined, and safety monitoring is discussed.
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