Anticholesterolemic effect of 3,4-di(OH)-phenylpropionic amides in high-cholesterol fed rats.

  title={Anticholesterolemic effect of 3,4-di(OH)-phenylpropionic amides in high-cholesterol fed rats.},
  author={Soon-ja Kim and Song Hae Bok and Sangku Lee and Hye-Jin Kim and Mi-Kyung Lee and Yong Bok Park and Myung‐Sook Choi},
  journal={Toxicology and applied pharmacology},
  volume={208 1},
Lipid Lowering and Antioxidant Effects of Newly Synthesized 4-((Butylsulfinyl)methyl)-1,2-benzenediol (SMBD) in Diet-induced Hypercholesterolemic Rabbits
Raised antioxidant effect of SMBD results in significant prevention against hypercholesterolemia and significantly inhibited the increase of aortic intimal thickness by 36% via reducing of aORTic reactive oxygen species and cyclooxygenase-2 protein levels.
Spirulina prevents atherosclerosis by reducing hypercholesterolemia in rabbits fed a high-cholesterol diet.
It is suggested that spirulina intake can cause the reduction of hypercholesterolemic atherosclerosis, associated with a decrease in levels of serum TC, TG and LDL-C, and an elevation of HDL-C level, and Spirulina may, therefore, be beneficial in preventing Atherosclerosis and reducing risk factors for cardiovascular diseases.
Butterbur (Petasites japonicus Max.) extract improves lipid profiles and antioxidant activities in monosodium L-glutamate-challenged mice.
It was proposed that BMP improve the plasma lipid profiles and decrease the oxidative stress by up-regulating the hepatic antioxidant enzymes in mice challenged with monosodium l-glutamate.
2,5-dihydroxy cinnamic acid (1), when fermented with fungal culture, Rhizopus oryzae RCMB 014002 gave mainly two metabolites; 2,5-dihydroxy cinnamoyl alcohol (CinRM-1) and 2-Hydroxy-4,5-dimethoxy
Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans.
Human urine was collected over a 24 h period after the consumption of 250 mL of (i) water, (ii) orange juice, and (iii) orange juice plus 150 mL of full fat natural yoghurt. The orange juice
Anti-diabetic, lipid lowering and antioxidant potential of Girardinia heterophylla in high fat diet and streptozotocin induced diabetic rats
From the results of the present study, ethanol extract of Girardinia heterophylla offers promising antidiabetic, lipid lowering and antioxidant potential that may be mainly attributed to its potent antioxidant properties.
Continuous hydrothermal synthesis of 3,4-dihydroxyhydrocinnamic acid-modified magnetite nanoparticles with stealth-functionality against immunological response
The synthesized Fe3O4 had no immune stimulating property for the dendritic cells of the mouse and is suitable for biological applications such as magnetic resonance imaging contrast agents and carriers for drug and gene delivery, and in areas such as hyperthermia therapy for cancer, biosensors, and tissue engineering.
Hydrothermal synthesis of inorganic-organic hybrid gadolinium hydroxide nanoclusters with controlled size and morphology.
A series of gadolinium hydroxide [Gd(OH)3] nanoclusters having different morphologies was synthesized in the presence of 3,4-dihydroxy hydrocinnamic acid (DHCA), an organic modifier, under
Surfactant-assisted one-pot synthesis of superparamagnetic magnetite nanoparticle clusters with tunable cluster size and magnetic field sensitivity.
All prepared clusters displayed superparamagnetic properties at room temperature, and the sensitivity of Fe(3)O(4) to an external magnetic field could also be controlled by the cluster size.


Lipid-lowering and antioxidative activities of 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate in cholesterol-fed rats.
  • J. Lee, M. Choi, S. Bok
  • Biology
    Clinica chimica acta; international journal of clinical chemistry
  • 2001
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.
  • A. Alberts, J. Chen, J. Springer
  • Chemistry, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1980
It was shown that mevinolin was an orally active cholesterol-lowering agent in the dog and orally administered sodium mevinolinate was an active inhibitor of cholesterol synthesis in an acute assay.
RG 12561 (dalvastatin): a novel synthetic inhibitor of HMG-CoA reductase and cholesterol-lowering agent.
In WHHL rabbits and cholestyramine-fed hamsters, RG 12561 and lovastatin reduced serum cholesterol by 17 and 16%, respectively, and these results demonstrate thatRG 12561 is a potent cholesterol-lowering agent.
Inhibition of 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis by the naturally occurring plant phenolics caffeic, ellagic, chlorogenic and ferulic acids.
The modifying effects of dietary administration of the plant phenolic antioxidants caffeic acid (CA), ellagic acid (EA), chlorogenic acid (CGA) and ferulic acid (FA) during the initiation phase on
Effect of ethyl esterification of phenolic acids on low-density lipoprotein oxidation.
CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption.
CL 277,082 (I) was a potent inhibitor of cholesterol absorption in cholesterol-fed rats by markedly inhibiting increases in liver and serum cholesterol concentration while increasing the excretion of neutral 14C-labeled sterol in the feces.
Characterization of metabolites of hydroxycinnamates in the in vitro model of human small intestinal epithelium caco-2 cells.
Results show that the in vitro model system differentiated Caco-2 cells have the capacity to metabolize dietary hydroxycinnamates, including various phase I (de-esterification) and phase II (glucuronidation, sulfation, and O-methylation) reactions, and suggests that the human small intestinal epithelium plays a role in the metabolism and bioavailability of these phenolic compounds.