Anticataleptic effects of the N-methyl-D-aspartate antagonist MK-801 in rats.

  title={Anticataleptic effects of the N-methyl-D-aspartate antagonist MK-801 in rats.},
  author={Werner H. Schmidt and Michael Bubser},
  journal={Pharmacology, biochemistry, and behavior},
  volume={32 3},
The N-methyl-D-aspartate (NMDA) antagonist MK-801 was administered to rats in three doses (0.08, 0.16, 0.33 mg/kg) in order to examine its effects on catalepsy that was induced by haloperidol (0.5 mg/kg). The degree of catalepsy was assessed 30 and 60 min after application of drugs by placing the rat on a horizontal bar, on a podium and on a vertical grid. Animals having received saline and haloperidol showed a higher degree of catalepsy than animals having received MK-801 and haloperidol… CONTINUE READING

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