Anticancer properties of the IL-12 family--focus on colorectal cancer.

  title={Anticancer properties of the IL-12 family--focus on colorectal cancer.},
  author={Matthias Agop Engel and Markus F Neurath},
  journal={Current medicinal chemistry},
  volume={17 29},
The prominent role of interleukin (IL)-12 in inflammatory responses, especially in TH1 T cell differentiation, is well established. Moreover, in murine models of tumorigenesis, IL-12 displays remarkable antitumor properties that are mainly mediated by interferon (IFN)-γ secretion by CD4+, CD8+ T cells, natural killer (NK) or NK-T cells. Importantly, IL-12 through IFN- γ -dependent induction of the antiangiogenic factors interferon-inducible protein (IP) 10 and monokine induced by gamma… CONTINUE READING


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