Anticancer nitrosoureas: investigations on antineoplastic, toxic and neoplastic activities.

@article{Eisenbrand1984AnticancerNI,
  title={Anticancer nitrosoureas: investigations on antineoplastic, toxic and neoplastic activities.},
  author={Gerhard Eisenbrand},
  journal={IARC scientific publications},
  year={1984},
  volume={57},
  pages={
          695-708
        }
}
Nitrosoureas are among the most effective antineoplastic drugs in experimental models. New water-soluble analogues have been tested extensively in preclinical studies, and the results show that new congeners, such as 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl)urea (HECNU), are more effective antineoplastic agents in most model systems than are clinically used compounds, such as 1,3-bis(2-chloroethyl)-1-nitrosourea or chlorozotocin. In chronic toxicity studies in rats, however, HECNU was… CONTINUE READING

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