Corpus ID: 3979673

Anticancer effects of kaempferol in A375 human malignant melanoma cells are mediated via induction of apoptosis, cell cycle arrest, inhibition of cell migration and downregulation of m-TOR/PI3K/AKT pathway.

@article{Yang2018AnticancerEO,
  title={Anticancer effects of kaempferol in A375 human malignant melanoma cells are mediated via induction of apoptosis, cell cycle arrest, inhibition of cell migration and downregulation of m-TOR/PI3K/AKT pathway.},
  author={Jia Yang and Peng Xiao and Jiaming Sun and Liang Guo},
  journal={Journal of B.U.ON. : official journal of the Balkan Union of Oncology},
  year={2018},
  volume={23 1},
  pages={
          218-223
        }
}
  • Jia Yang, Peng Xiao, +1 author Liang Guo
  • Published 2018
  • Chemistry, Medicine
  • Journal of B.U.ON. : official journal of the Balkan Union of Oncology
PURPOSE Melanoma is an aggressive form of human cancer with limited treatment options currently available. The present study was aimed to evaluate the anticancer activity of kaempferol (KAM) against the human malignant melanoma A375 cell line along with evaluation of its effects on apoptosis, cell cycle, cell migration and m-TOR/PI3K/AKT pathway. METHODS Effects on cell viability were assessed by MTT assay while clonogenic assay measured the effects of KAM on colony formation. Annexin V assay… Expand
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