Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines.

@article{Faried2007AnticancerEO,
  title={Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines.},
  author={Ahmad Faried and Dikdik Kurnia and Leri S. Faried and Nurhayat Usman and Tatsuya Miyazaki and Hoichi Kato and Hiroyuki Kuwano},
  journal={International journal of oncology},
  year={2007},
  volume={30 3},
  pages={605-13}
}
The natural antioxidant gallic acid (GA) was isolated from fruits of a medicinal Indonesian plant, Phaleria macrocarpa (Scheff.) Boerl. The structure was identified on the basis of spectroscopic analysis and comparison with authentic compound. GA demonstrated a significant inhibition of cell proliferation in a series of cancer cell lines and induced apoptosis in esophageal cancer cells (TE-2) but not in non-cancerous cells (CHEK-1). Observation of the molecular mechanism of apoptosis showed… CONTINUE READING

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