Anticancer drugs targeting the mitochondrial electron transport chain.

  title={Anticancer drugs targeting the mitochondrial electron transport chain.},
  author={Jakub Rohlena and L Dong and Stephen John Ralph and Jiri Neuzil},
  journal={Antioxidants & redox signaling},
  volume={15 12},
SIGNIFICANCE Mitochondria are emerging as highly intriguing organelles showing promise but that are yet to be fully exploited as targets for anticancer drugs. RECENT ADVANCES A group of compounds that induce mitochondrial destabilization, thereby affecting the physiology of cancer cells, has been defined and termed 'mitocans.' Based on their mode of action of targeting in and around mitochondria, we have placed these agents into several groups including hexokinase inhibitors, compounds… CONTINUE READING
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