Anticancer drugs induce mdr1 gene expression in recurrent ovarian cancer.

  title={Anticancer drugs induce mdr1 gene expression in recurrent ovarian cancer.},
  author={Stephanie Hille and Daniel T. Rein and Marion Riffelmann and Rainer Neumann and Judith Sartorius and A Pf{\"u}tzner and Christian Martin Kurbacher and Thomas Sch{\"o}ndorf and Martina Breidenbach},
  journal={Anti-cancer drugs},
  volume={17 9},
Ovarian cancer is currently the most lethal gynecologic malignancy in Europe and the US. Platin analogues and paclitaxel demonstrate high remission rates, but unfortunately the efficacy of cytostatic agents is limited by the development of multidrug resistance (mdr). Clinical paclitaxel resistance is often associated with mdr1 overexpression. In a recent study, we introduced a highly specific quantitative real-time reverse transcriptase polymerase chain reaction for the quantification of mdr1… CONTINUE READING