Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction.

@article{Wesselborg1999AnticancerDI,
  title={Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction.},
  author={Sebastian Wesselborg and Ingo Hubert Engels and Evelyn Rossmann and Marek Jan Los and Klaus Schulze-Osthoff},
  journal={Blood},
  year={1999},
  volume={93 9},
  pages={3053-63}
}
Proteases of the caspase family are the critical executioners of apoptosis. Their activation has been mainly studied upon triggering of death receptors, such as CD95 (Fas/APO-1) and tumor necrosis factor-R1, which recruit caspase-8/FLICE as the most proximal effector to the receptor complex. Because apoptosis induced by anticancer drugs has been proposed to involve CD95/CD95 ligand interaction, we investigated the mechanism of caspase activation by daunorubicin, doxorubicin, etoposide, and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 129 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 68 references

Similar Papers

Loading similar papers…