Anticancer drug mithramycin interacts with core histones: An additional mode of action of the DNA groove binder

@article{Banerjee2014AnticancerDM,
  title={Anticancer drug mithramycin interacts with core histones: An additional mode of action of the DNA groove binder},
  author={Amrita Banerjee and S. Sanyal and Kirti K. Kulkarni and K. Jana and S. Roy and Chandrima Das and D. Dasgupta},
  journal={FEBS Open Bio},
  year={2014},
  volume={4},
  pages={987 - 995}
}
  • Amrita Banerjee, S. Sanyal, +4 authors D. Dasgupta
  • Published 2014
  • Biology, Medicine
  • FEBS Open Bio
  • Mithramycin (MTR) is a clinically approved DNA‐binding antitumor antibiotic currently in Phase 2 clinical trials at National Institutes of Health for treatment of osteosarcoma. In view of the resurgence in the studies of this generic antibiotic as a human medicine, we have examined the binding properties of MTR with the integral component of chromatin – histone proteins – as a part of our broad objective to classify DNA‐binding molecules in terms of their ability to bind chromosomal DNA alone… CONTINUE READING
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