Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells.

  title={Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells.},
  author={Yuting Ma and Sandy Adjemian and Stephen R. Mattarollo and Takahiro Yamazaki and Laetitia Aymeric and Heng Yang and Jo{\~a}o Paulo Portela Catani and Dalil Hannani and H{\'e}l{\`e}ne Duret and Kim Steegh and Isabelle Christine V. S. Martins and Fr{\'e}d{\'e}ric Schlemmer and Mick{\"a}el Michaud and Oliver Kepp and Abdul Qader Sukkurwala and Laurie Menger and Erika Vacchelli and Nathalie Droin and Lorenzo Galluzzi and Roman Krzysiek and Siamon Gordon and Philip R. Taylor and Peter van Endert and {\'E}ric Solary and Mark J Smyth and Laurence Zitvogel and Guido Kroemer},
  volume={38 4},
The therapeutic efficacy of anthracyclines relies on antitumor immune responses elicited by dying cancer cells. How chemotherapy-induced cell death leads to efficient antigen presentation to T cells, however, remains a conundrum. We found that intratumoral CD11c(+)CD11b(+)Ly6C(hi) cells, which displayed some characteristics of inflammatory dendritic cells and included granulomonocytic precursors, were crucial for anthracycline-induced anticancer immune responses. ATP released by dying cancer… CONTINUE READING
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