Anticancer and chemosensitizing abilities of cycloviolacin 02 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa.

@article{Gerlach2010AnticancerAC,
  title={Anticancer and chemosensitizing abilities of cycloviolacin 02 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa.},
  author={Samantha L. Gerlach and Ramesh Rathinakumar and Geetika Chakravarty and Ulf G{\"o}ransson and William C. Wimley and Steven P. Darwin and Debasis Mondal},
  journal={Biopolymers},
  year={2010},
  volume={94 5},
  pages={
          617-25
        }
}
Cycloviolacin O2 (CyO2), a cyclotide from Viola odorata (Violaceae) has antitumor effects and causes cell death by membrane permeabilization. In the breast cancer line, MCF-7 and its drug resistant subline MCF-7/ADR, the cytotoxic effects of CyO2 (0.2-10 microM) were monitored in the presence and absence of doxorubicin (0.1-5 microM) using cell proliferation assays to establish its chemosensitizing abilities. SYTOX Green assays were Sperformed to verify membrane permeabilization and showed… CONTINUE READING

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