Anticancer and cancer chemopreventive potential of grape seed extract and other grape-based products.

  title={Anticancer and cancer chemopreventive potential of grape seed extract and other grape-based products.},
  author={Manjinder Kaur and Chapla Agarwal and Rajesh Agarwal},
  journal={The Journal of nutrition},
  volume={139 9},
With emerging trends in the incidence of cancer of various organ sites, additional approaches are needed to control human malignancies. Intervention or prevention of cancer by dietary constituents, a strategy defined as chemoprevention, holds great promise in our conquest to control cancer, because it can be implemented on a broader population base with less economic burden. Consistent with this, several epidemiological studies have shown that populations that consume diets rich in fruits and… 


GSE-related anti-cancer activity mostly relies on the induced increase in reactive oxygen species, followed by the orchestrated downand up-regulation of several key-molecular pathways, including MAPK kinases, PI3K/Akt, NF-kB, cytoskeleton proteins and metalloproteinases.

Anticancer Effects of Grape Seed Extract on Human Cancers: A Review

Promising results obtained in vitro as well as on animal studies suggest that GSE may have a great relevance as source of potential new pharmacological molecules, and could represent an important opportunity for clinical research.

Potential Anticancer Properties of Grape Antioxidants

It is demonstrated that consumption of grape, wine and grape juice exerts many health-promoting and possible anti-cancer effects and grape skin and seed extracts have great potential in cancer prevention and further investigation into this exciting field is warranted.

Ginger Phytochemicals Exhibit Synergy to Inhibit Prostate Cancer Cell Proliferation

Interestingly, combining GE with its constituents (in particular, 6-gingerol) resulted in significant augmentation of GE's antiproliferative activity, generating compelling grounds for further preclinical evaluation of GE alone and in combination with individual ginger biophenols for prostate cancer management.

Phytochemicals in Cancer Prevention: A Review of the Evidence

Regular intake of phytochemicals has been demonstrated to prevent cancer during its different stages including initiation, promotion and progression and Considering the animal models, the second step is the main stage for cancer chemoprevention.

Potent anti-cancer effects of citrus peel flavonoids in human prostate xenograft tumors.

The findings suggest that GL is an effective anti-cancer agent that may potentially serve as a novel therapeutic option for prostate cancer treatment.

Effects of Dietary Components on Cancer of the Digestive System

The present review illustrates the main foods and their active components, including their antioxidant, cytotoxic, and pro-apoptotic properties, with a particular focus on the evidence related to cancers of the digestive system.

Potential of grape polyphenols as breast cancer therapeutics

Abstract Introduction Grape and red wine polyphenols have long been purported to have multiple health benefits. Although convincing clinical data are still lacking, recent experimental studies have

Experimental Evaluation of the Effectiveness of Resveratrol as an Antioxidant in Colon Cancer Prevention

Administrating resveratrol along with 1,2-dimethylhydrazine during 30 weeks led to the inhibition of oxidative stress manifestations, in particular, lipid peroxidation and morphological changes in the colon tissue of the animals that obtained resver atrol + DMH could be characterized as signs of mucous colitis.

Grape Phytochemicals and Associated Health Benefits

  • Jun YangYang Xiao
  • Biology, Medicine
    Critical reviews in food science and nutrition
  • 2013
The aim of this paper is to critically review the most recent literature regarding the concentrations, biological activities, and mechanisms of grape phytochemicals.



Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.

Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways.

  • S. Ramos
  • Biology, Chemistry
    Molecular nutrition & food research
  • 2008
Insight is provided into the molecular basis of potential chemopreventive and therapeutic activities of dietary polyphenols with emphasis in their ability to control intracellular signalling cascades considered as relevant targets in a cancer preventive approach.

Grape Seed Extract Inhibits In vitro and In vivo Growth of Human Colorectal Carcinoma Cells

GSE may be an effective chemopreventive agent against colorectal cancer, and that growth inhibitory and apoptotic effects of GSE could be mediated via an up-regulation of Cip1/p21.

Chemoprevention by grape seed extract and genistein in carcinogen-induced mammary cancer in rats is diet dependent.

It is demonstrated that GSE is chemopreventive in an animal model of breast cancer; moreover, the diet dependency of the chemopareventive activity for both GSE and genistein suggests that whether or not a compound isChemopreventionive may depend on the diet in which the agent is administered.

Cranberry and Grape Seed Extracts Inhibit the Proliferative Phenotype of Oral Squamous Cell Carcinomas

Comparisons provide evidence that cranberry and grape seed extracts not only inhibit oral cancer proliferation but also that the mechanism of this inhibition may function by triggering key apoptotic regulators in these cell lines.

Grape seed proanthocyanidines and skin cancer prevention: inhibition of oxidative stress and protection of immune system.

  • S. Katiyar
  • Biology, Medicine
    Molecular nutrition & food research
  • 2008
In SKH-1 hairless mice, dietary supplementation with GSPs is associated with a decrease of UVB-induced skin tumor development in terms of tumor incidence, tumor multiplicity, and a decrease in the malignant transformation of papillomas to carcinomas, and it is suggested that dietary G SPs could be useful in the attenuation of the adverse UV-induced health effects in human skin.

Potential of resveratrol in anticancer and anti-inflammatory therapy.

Resveratrol possesses good potential to be used as an adjunctive or alternative therapy for cancer and inflammatory diseases and has been shown to produce no adverse effects, even when consumed at high concentrations.

Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms.

The results show that MSKE and resveratrol target distinct pathways to inhibit prostate cancer cell growth in this system and that the unique properties of MSKE suggest that it may be an important source for further development of chemopreventive or therapeutic agents against prostate cancer.

Natural products as inhibitors of carcinogenesis

Despite the obstacles that must be overcome before chemopreventive drugs become an integral component of standard medical practice for cancer prophylaxis, there is vast potential for significant improvement in cancer morbidity and mortality through the use of natural products as inhibitors of carcinogenesis.