Anticancer and antimicrobial metallopharmaceutical agents based on palladium, gold, and silver N-heterocyclic carbene complexes.

@article{Ray2007AnticancerAA,
  title={Anticancer and antimicrobial metallopharmaceutical agents based on palladium, gold, and silver N-heterocyclic carbene complexes.},
  author={Sriparna Datta Ray and Renu Mohan and Jay Kumar Singh and Manoja K Samantaray and M. Mobin Shaikh and Dulal Panda and Prasenjit Ghosh},
  journal={Journal of the American Chemical Society},
  year={2007},
  volume={129 48},
  pages={15042-53}
}
Complete synthetic, structural, and biomedical studies of two Pd complexes as well as Au and Ag complexes of 1-benzyl-3-tert-butylimidazol-2-ylidene are reported. Specifically, trans-[1-benzyl-3-tert-butylimidazol-2-ylidene]Pd(pyridine)Cl2 (1a) was synthesized from the reaction of 1-benzyl-3-tert-butylimidazolium chloride (1) with PdCl2 in the presence of K2CO3 as a base. The other palladium complex, [1-benzyl-3-tert-butylimidazol-2-ylidene]2PdCl2 (1b), and a gold complex, [1-benzyl-3-tert… CONTINUE READING

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