Anticancer activity of the cholesterol exporter ABCA1 gene.

  title={Anticancer activity of the cholesterol exporter ABCA1 gene.},
  author={Bradley Smith and Hartmut Land},
  journal={Cell reports},
  volume={2 3},
The ABCA1 protein mediates the transfer of cellular cholesterol across the plasma membrane to apolipoprotein A-I. Loss-of-function mutations in the ABCA1 gene induce Tangier disease and familial hypoalphalipoproteinemia, both cardiovascular conditions characterized by abnormally low levels of serum cholesterol, increased cholesterol in macrophages, and subsequent formation of vascular plaque. Increased intracellular cholesterol levels are also frequently found in cancer cells. Here, we… CONTINUE READING


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