Anticancer activity of chemically prepared shrimp low molecular weight chitin evaluation with the human monocyte leukaemia cell line, THP-1.

@article{Salah2013AnticancerAO,
  title={Anticancer activity of chemically prepared shrimp low molecular weight chitin evaluation with the human monocyte leukaemia cell line, THP-1.},
  author={Rym Salah and Philippe Michaud and Fatima Guiet Mati and Zoubir Harrat and Hakim Lounici and Nadia Abdi and Nadjib Drouiche and Nabil Mameri},
  journal={International journal of biological macromolecules},
  year={2013},
  volume={52},
  pages={333-9}
}
In the present study, anticancer activities of chitin, chitosan and low molecular weight chitin were evaluated using a human tumour cell line, THP-1. A molecular weight-activity relationship and an electrostatic interaction-activity relationship were determined. The cytotoxic effects of chitin and derivatives were also evaluated using a normal human foetal lung fibroblastic cell line, MRC-5 and the specific cytotoxicity of chitin and derivatives to tumour cell lines was demonstrated. The high… CONTINUE READING

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