Anticancer SAR establishment and novel accruing signal transduction model of drug action using biscoumarin scaffold.

@article{Mayank2019AnticancerSE,
  title={Anticancer SAR establishment and novel accruing signal transduction model of drug action using biscoumarin scaffold.},
  author={Mayank and Abhilakh Kumar Singh and Navneet Kaur and Neha Garg and N D Pradeep Singh},
  journal={Computational biology and chemistry},
  year={2019},
  volume={83},
  pages={
          107104
        }
}
In this paper, we have established methylenebis (4-hydroxy-2H-chromen-2-one) as a promising anticancer scaffold with kinesin spindle protein (KSP) inhibitory activity under malignant condition. A series of biscoumarin derivatives (MN1 to MN30) with different substituent were synthesized, and their anticancer activity was explored. Six biscoumarin derivatives that were found active were further selected to formulate organic nanoparticles (ONPs). Anticancer activity of both the forms (viz… CONTINUE READING

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