Anticancer Drugs, Ionophoric Peptides, and Steroids as Substrates of the Yeast Multidrug Transporter Pdr5p*

  title={Anticancer Drugs, Ionophoric Peptides, and Steroids as Substrates of the Yeast Multidrug Transporter Pdr5p*},
  author={Marcin Kołaczkowski and van der Rest Michel and Anna Cybularz-Kolaczkowska and J. P. Soumillion and Wilhelmus Nicolaas Konings and Goffeau Andr{\'e}},
  journal={The Journal of Biological Chemistry},
  pages={31543 - 31548}
Pdr5p is the yeast Saccharomyces cerevisiae ATP-binding cassette transporter conferring resistance to several unrelated drugs. Its high overproduction in Pdr1p transcription factor mutants allows us to study the molecular mechanism of multidrug transport and substrate specificity. We have developed new in vivo and in vitro assays of Pdr5p-mediated drug transport. We show that in spite of little sequence homology, and inverted topology in respect to that of mammalian P-glycoproteins, Pdr5p… 

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