Corpus ID: 86027254

Anticancer Activity of Withania Somnifera (Leaves) Flavonoids Compound

@inproceedings{Nema2013AnticancerAO,
  title={Anticancer Activity of Withania Somnifera (Leaves) Flavonoids Compound},
  author={Rajeev Nema and Sarita Khare and Parul Jain and A. A. Pradhan and Shivaji Nagar},
  year={2013}
}
In this research article make known on Withania somnifera (Ashwagandha) as Medicinal plants have therapeutic potential due to the presence of natural antioxidants functioning as reducing agents, free radical scavengers and quenchers of singlet oxygen. And this article also determines the use of Withania Somnifera (leaves) Polyphenolic Compound activity on MCF-7, A549 and PA-1 cancer cell line (breast, lung and ovary respectively). By providing a scientific basis the study can be made… 

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References

SHOWING 1-10 OF 26 REFERENCES
Immunomodulatory activity of Withania somnifera.
TLDR
The results confirm the immunomodulatory activity of W. somnifera extract, which is a known immunosorbent in indigenous medicine, and Administration of Withania extract inhibited delayed type hypersentivity reaction in mice.
The protective effect of a purified extract of Withania somnifera against doxorubicin-induced cardiac toxicity in rats
TLDR
Withania may play a role in the protection against cardiotoxicity and thus might be a useful adjuvant therapy where doxorubicin is the cancer-treating drug.
Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha.
  • K. Kaur, G. Rani, +4 authors R. Wadhwa
  • Biology, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2004
TLDR
It is found that the Lash from field-raised plants has a significant anti-proliferative activity in human tumorigenic cells, but it did not impart any protection against the oxidative damage caused by high glucose and hydrogen peroxide to human tumor cells suggesting that it can be used as an anti-tumor, but not as anAnti-oxidant, substance.
Anti-malarial activity of withania somnifera L. Dunal extracts in mice.
OBJECTIVE This study aims at investigating the in vivo antiplasmodial activity of a traditionally used medicinal plant, Withania somnifera, L. Dunal, (Solanaceae). METHODS Rodent malaria parasite,
Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study.
TLDR
Investigation of the anxiolytic and antidepressant actions of the bioactive glycowithanolides of Withania somnifera, isolated from WS roots, in rats support the use of WS as a mood stabilizer in clinical conditions of anxiety and depression in Ayurveda.
Toxicity of Withania Somnifera Root Extract in Rats and Mice
TLDR
Subacute Toxicity Studies With Repeated Injections of Ashwagandha Extract At A Dose Of 100 Mg/Kg Body Wt.
Antimicrobial properties of a non‐toxic glycoprotein (WSG) from Withania somnifera (Ashwagandha)
TLDR
Antifungal effect has been demonstrated in that WSG exerts a fungistastic effect by inhibiting spore germination and hyphal growth in the tested fungi.
Cyclooxygenase-2 enzyme inhibitory withanolides from Withania somnifera leaves
Abstract Four novel withanolide glycosides and a withanolide have been isolated from the leaves of Withania somnifera . The structures of the novel compounds were elucidated as physagulin D (1→6)-β-
Spectroscopic determination of total phenol and flavonoid contents of Ipomoea carnea.
Quantitative determination of phenols and flavonoids in leaves, stem and flowers of Ipomoea carnea was carried out using spectrophotometric methods. Catechol and quercetin reagents were used as the
The neuroprotective effect of Withania somnifera root extract in MPTP-intoxicated mice: An analysis of behavioral and biochemical varibles
TLDR
Oral treatment with the root extract resulted in a significant improvement in the mice’s behavoiur and antioxidant status, along with a significant reduction in the level of lipid peroxidation, which indicated that at least part of the chronic stress-induced pathology may be due to oxidative stress, which is mitigated by Ws.
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3
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