Anticancer Activity of Sodium Stibogluconate in Synergy with IFNs1

@article{Yi2002AnticancerAO,
  title={Anticancer Activity of Sodium Stibogluconate in Synergy with IFNs1},
  author={T. Yi and M. K. Pathak and D. Lindner and M. Ketterer and C. Farver and E. Borden},
  journal={The Journal of Immunology},
  year={2002},
  volume={169},
  pages={5978 - 5985}
}
Cancer cell resistance limits the efficacy of IFNs. In this study, we show that sodium stibogluconate (SSG) and IFN-α synergized to overcome IFN-α resistance in various human cancer cell lines in culture and eradicated IFN-α-refractory WM9 human melanoma tumors in nude mice with no obvious toxicity. SSG enhanced IFN-α-induced Stat1 tyrosine phosphorylation, inactivated intracellular SHP-1 and SHP-2 that negatively regulate IFN signaling, and induced cellular protein tyrosine phosphorylation in… Expand
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