Anticancer Activity of Linalool Terpenoid: Apoptosis Induction and Cell Cycle Arrest in Prostate Cancer Cells

  title={Anticancer Activity of Linalool Terpenoid: Apoptosis Induction and Cell Cycle Arrest in Prostate Cancer Cells},
  author={Xiuyan Sun and Shaolan Wang and Tao Li and Yong-qing Yang},
  journal={Tropical Journal of Pharmaceutical Research},
Purpose : To evaluate the anticancer activity of linalool against human prostate cancer (DU145) cells. Methods : The anticancer activity of linalool against DU145 cancer cells was evaluated by 3-(4, 5- dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Flow cytometry, using propidium iodide and Annexin V-FITC, was applied to study apoptosis and cell cycle phase distribution. Inverted light microscopy was used to study the effect of linalool on cell morphology and apoptotic body… 

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