Anticancer β-hairpin peptides: membrane-induced folding triggers activity.

  title={Anticancer β-hairpin peptides: membrane-induced folding triggers activity.},
  author={Chomdao Sinthuvanich and Ana Salom{\'e} Veiga and Kshitij Gupta and Diana Gaspar and Robert Blumenthal and Joel P Schneider},
  journal={Journal of the American Chemical Society},
  volume={134 14},
Several cationic antimicrobial peptides (AMPs) have recently been shown to display anticancer activity via a mechanism that usually entails the disruption of cancer cell membranes. In this work, we designed an 18-residue anticancer peptide, SVS-1, whose mechanism of action is designed to take advantage of the aberrant lipid composition presented on the outer leaflet of cancer cell membranes, which makes the surface of these cells electronegative relative to the surface of noncancerous cells… CONTINUE READING
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