Antibody validation by quantitative analysis of protein expression using expression of Met in breast cancer as a model

@article{PoznerMoulis2007AntibodyVB,
  title={Antibody validation by quantitative analysis of protein expression using expression of Met in breast cancer as a model},
  author={Sharon Pozner-Moulis and Melissa Cregger and Robert L. Camp and David L. Rimm},
  journal={Laboratory Investigation},
  year={2007},
  volume={87},
  pages={251-260}
}
Expression of Met, the Hepatocyte Growth Factor receptor, has been shown to have prognostic value in numerous types of cancer including breast, gastric, cervical and head and neck carcinomas. However, traditional analyses of expression have shown variable results and a lack of reproducibility. The AQUA® system is a method of quantitative in situ analysis of protein expression that allows the assessment of reproducibility of both antibodies and assay conditions. Here, we illustrate the necessity… CONTINUE READING