Antibody valence and induced signal transduction: the role of antibody valence in anti-CD3-induced signal transduction in isolated normal T cells.

@article{Melton1989AntibodyVA,
  title={Antibody valence and induced signal transduction: the role of antibody valence in anti-CD3-induced signal transduction in isolated normal T cells.},
  author={L B Melton and Fadi G Lakkis and M Moscovitch-Lopatin and Brian Richard Smith and Julie M. Williams and Philip M. Rosoff and Terry B. Strom},
  journal={Clinical immunology and immunopathology},
  year={1989},
  volume={50 2},
  pages={171-83}
}
This report provides direct evidence that protein kinase C (PKC) is activated in isolated, rigorously accessory cell (AC)-depleted T cells when the T cell antigen recognition complex is stimulated by divalent anti-CD3 monoclonal antibody. Anti-CD3 monoclonal antibody-stimulated PKC activation alone does not, however, directly stimulate T cell proliferation in the absence of AC. A rise in cytosolic calcium is the second signal believed to be of paramount importance in T cell activation. While… CONTINUE READING