Antibody to the inositol trisphosphate receptor blocks thimerosal-enhanced Ca(2+)-induced Ca2+ release and Ca2+ oscillations in hamster eggs.

@article{Miyazaki1992AntibodyTT,
  title={Antibody to the inositol trisphosphate receptor blocks thimerosal-enhanced Ca(2+)-induced Ca2+ release and Ca2+ oscillations in hamster eggs.},
  author={Shunichi Miyazaki and Hideki Shirakawa and Kazuto Nakada and Yumiko Honda and Michisuke Yuzaki and Shinji Nakade and Katsuhiko Mikoshiba},
  journal={FEBS letters},
  year={1992},
  volume={309 2},
  pages={180-4}
}
The sulfhydryl reagent thimerosal enhanced the sensitivity of hamster eggs to injected inositol 1,4,5-trisphosphate (InsP3) or Ca2+ to generate regenerative Ca2+ release from intracellular pools. A monoclonal antibody (mAb) to the InsP3 receptor blocked both the InsP3-induced Ca2+ release (IICR) and Ca(2+)-induced Ca2+ release (CICR). The mAb also blocked Ca2+ oscillations induced by thimerosal. The results indicate that thimerosal enhances IICR sensitized by cytosolic Ca2+, but not CICR from… CONTINUE READING

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