Antibody to integrin alpha 6 subunit specifically inhibits cell-binding to laminin fragment 8.

@article{Aumailley1990AntibodyTI,
  title={Antibody to integrin alpha 6 subunit specifically inhibits cell-binding to laminin fragment 8.},
  author={Monique Aumailley and Rupert Timpl and Arnoud Sonnenberg},
  journal={Experimental cell research},
  year={1990},
  volume={188 1},
  pages={55-60}
}
A large number of cell lines which attach and spread on laminin show a comparable binding either to both laminin fragments P1 and E8 or exclusively to E8. Adhesion to fragment E8 was with one exception completely inhibited by a monoclonal antibody to the alpha 6 integrin subunit, indicating that VLA-6 or a related structure is the major cellular receptor… CONTINUE READING