Antibody to aquaporin-4 in the long-term course of neuromyelitis optica

  title={Antibody to aquaporin-4 in the long-term course of neuromyelitis optica},
  author={Sven Jarius and Fahmy Aboul-Enein and Patrick Waters and Bettina Kuenz and A. Hauser and Thomas F H Berger and Wilfried Lang and Markus Reindl and Angela Vincent and Wolfgang Kristoferitsch},
  pages={3072 - 3080}
Neuromyelitis optica (NMO) is a severe inflammatory CNS disorder of putative autoimmune aetiology, which predominantly affects the spinal cord and optic nerves. Recently, a highly specific serum reactivity to CNS microvessels, subpia and Virchow-Robin spaces was described in patients with NMO [called NMO-IgG (NMO-immunoglobulin G)]. Subsequently, aquaporin-4 (AQP4), the most abundant water channel in the CNS, was identified as its target antigen. Strong support for a pathogenic role of the… CONTINUE READING
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