Antibody to aquaporin-4 in the long-term course of neuromyelitis optica

@article{Jarius2008AntibodyTA,
  title={Antibody to aquaporin-4 in the long-term course of neuromyelitis optica},
  author={Sven Jarius and Fahmy Aboul-Enein and Patrick Waters and Bettina Kuenz and A. Hauser and Thomas F H Berger and Wilfried Lang and Markus Reindl and Angela Vincent and Wolfgang Kristoferitsch},
  journal={Brain},
  year={2008},
  volume={131},
  pages={3072 - 3080}
}
Neuromyelitis optica (NMO) is a severe inflammatory CNS disorder of putative autoimmune aetiology, which predominantly affects the spinal cord and optic nerves. Recently, a highly specific serum reactivity to CNS microvessels, subpia and Virchow-Robin spaces was described in patients with NMO [called NMO-IgG (NMO-immunoglobulin G)]. Subsequently, aquaporin-4 (AQP4), the most abundant water channel in the CNS, was identified as its target antigen. Strong support for a pathogenic role of the… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
159 Citations
18 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 159 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 18 references

Similar Papers

Loading similar papers…